Harnessing Targeted Protein Degradation:

Oxeltis combines synthetic agility, a modular E3 ligand binder and linker library, and seamless biological validation to accelerate your protein degradation program.

01 — WHAT MAKES US DIFFERENT

At Oxeltis, we specialize in Targeted Protein Degradation via PROTACs (Proteolysis-Targeting Chimeras), leveraging the cell's ubiquitin-proteasome system (UPS) to degrade disease-causing proteins, not just inhibit them. This breakthrough unlocks previously "undruggable" targets, transforming therapeutic options, especially in oncology.

More than a service provider, we are a dedicated scientific partner, guiding you from discovery to optimization. Our internal library of E3 ligase ligands and linkers, including VHL and CRBN binders, as well as PEG-based, alkyl, rigid heteroaromatic, and click-chemistry-compatible linkers, enables rapid, modular assembly of diverse PROTAC libraries.

To stay ahead of the curve, our project managers conduct weekly bibliographic reviews, ensuring our strategies are always informed by the latest advancements in the field.

Key differentiators

In-house E3 ligand library

(>1 g available) covering VHL and CRBN binders enabling rapid PROTAC assembly without lead times on key building blocks

Modular linker library

(PEG-based, alkyl, rigid heteroaromatic, click-chemistry-compatible) for independent optimization of each PROTAC component

Advanced synthetic toolkit

flow chemistry for hazardous transformations, photochemistry for selective functionalization, and high-performance SFC for complex chiral intermediates

Weekly bibliographic reviews

by project managers, strategies informed by the latest PROTAC literature

Integrated consortium

in silico ternary complex modeling with computational partners and biological validation via Partex.ai

02 — CAPABILITIES

Our PROTAC approach: from concept to optimization

Each capability below directly addresses a recurring challenge in heterocyclic scaffold synthesis for drug discovery programs.

Modular, Precision PROTAC Synthesis

Efficient synthetic routes designed to rapidly generate diverse PROTAC libraries, allowing independent optimization of each component (warhead, linker, and E3 ligand) without rebuilding from scratch at each iteration.

Linker Design & Optimization

The linker is more than a molecular bridge, it is a critical pharmacophore. We explore a wide range of linker architectures to control geometry, metabolic stability, and solubility, accelerating the identification of productive ternary complexes.

Advanced Synthetic Technologies

Flow chemistry for hazardous or exothermic transformations, photochemistry for selective functionalization, and high-performance SFC for purification of complex chiral intermediates, deployed where standard batch chemistry reaches its limits.

Biological Validation via Partex.ai Labs

Our partner Partex.ai performs biological assays such as Western Blot experiments, nanoBRET target engagment, Hibit providing robust, high-throughput validation of PROTAC degradation activity, ensuring a seamless transition from chemical design to biological proof-of-concept.

Equipment & technology highlights

Flow chemistry
Photochemistry
High-performance SFC
Modular PROTAC libraries
E3 ligand library (VHL, CRBN)
LC-MS (analytical & preparative)
NMR (¹H, ¹³C, 2D)

03 — PROTAC Proof of Concept Service

Streamlined Proof of Concept methodology

We offer a structured POC approach to rapidly assess over 3 months the feasibility of degrading your target protein.

Exit Vector Identification

Pinpointing optimal binding sites on your protein of interest (POI) to anchor the PROTAC warhead.

Initial PROTAC Library Synthesis

Creating an initial library with variations in linker length, rigidity, and E3 ligase binder to explore the ternary complex space.

Degradation Evaluation

Testing protein degradation via Western Blot at two concentrations, with optional early kinetics analysis (D_max, DC₅₀).

Data-Driven Go/No-Go Decision

Joint review of degradation results to determine whether to transition into a full Lead Optimization program.

Ready to transform your inhibitor into a powerful degrader?

Whether exploring a first-generation PROTAC concept, optimizing a lead series, or scaling up for IND-enabling studies.
Contact us to discuss your project.