Peptide-Chemistry - oxeltis.studiokg.fr

Peptide and Peptido Mimetics Chemistry & Synthesis

From challenging linear sequences (15-20 mers) to macrocyclic/bicyclic and conjugation-ready peptides, Oxeltis delivers high-purity custom peptides through solid-phase peptide synthesis (SPPS), solution-phase, and hybrid strategies.

01 — WHAT MAKES US DIFFERENT

Peptides bridge chemistry and biology, offering unmatched selectivity and relevance as therapeutics, tools, and scaffolds. However, their synthesis, non-standard amino acids or macrocyclization, demands advanced expertise.

At Oxeltis, we specialize in custom peptide synthesis, tailoring Fmoc, Boc SPPS, solution-phase, and hybrid approaches to each sequence. Our PhD and M.Sc. chemists leverage organic synthesis expertise to design robust, scalable routes and preempt challenges.

We adapt to the unpredictable: sequences evolve, biological feedback reshapes designs, and timelines shift. As your integrated scientific partner, we engage in SAR discussions, adjust strategies in real time, and deliver excellence, whether for a single peptide, SAR libraries, or scalable clinical routes.

Key differentiators

Full synthetic flexibility

SPPS (Fmoc/Boc), solution-phase, and hybrid convergent strategies, not a single-protocol facility

Genuine macrocyclization expertise

on-resin and in-solution cyclization, lactam formation, and RCM stapling via non-natural amino acid cross-links

PhD-level chemists

with fine organic synthesis background capable of tackling non-standard building blocks and novel structural motifs

Integrated consortium model

synthesized peptides flow directly into biological screening (Partex.ai) and CADD-guided redesign (Molecular Forecaster)

02 — CAPABILITIES

What we can do for your peptide program

Each capability below directly addresses a recurring challenge in peptide synthesis for drug discovery programs.

Solid-Phase Peptide Synthesis (SPPS) Fmoc & Boc strategies

Expert selection of resin, coupling reagents, and deprotection conditions tailored to each sequence. Optimized coupling cycles to minimize epimerization, deletion sequences, and low-yield steps.

Solution-Phase Synthesis & Convergent Fragment Condensation

When solid-phase approaches reach their limits, we bring solution-phase strategies and convergent fragment condensation to the table.

Macrocyclization & Structural Constraint

Conformational control for enhanced selectivity, cell permeability, and proteolytic stability. Our capabilities include on-resin and in-solution macrocyclization, lactam cyclization, and ring-closing metathesis (RCM) for peptide stapling via non-natural amino acid cross-links.

Non-Proteinogenic & Non-Standard Building Blocks

Incorporation of D-amino acids, β-amino acids, N-methylated residues, and other non-canonical building blocks to improve proteolytic stability, tune pharmacology, or address specific SAR hypotheses. Custom building block synthesis where commercial sources are unavailable.

Conjugation-Ready Peptides

Sequences equipped with orthogonal reactive handles (azides, alkynes, maleimides, NHS esters, and more) for downstream conjugation to ADC payloads, fluorescent labels, PEG chains, or other functional modules — delivered with full analytical characterization of the functionalized peptide.

Analytical Rigor & Full Characterization

Every peptide delivered by Oxeltis is fully characterized by HPLC purity assessment, LC-MS, and NMR spectroscopy where required.

Equipment & technology highlights

SPPS synthesizer (Fmoc/Boc)
Hybrid SFC purification platform
LC-MS (analytical & preparative)
HRMS
NMR (1H, 13C, 2D)
RCM / olefin metathesis
Chiral resolution by SFC

The Challenge

Required solid-phase synthesis optimization focusing on rapid block-coupling times to achieve high-yield peptoids under tight timelines.

Oxeltis Approach

Developed and optimized the synthetic route on the peptoid hit by screening ~20 parallel conditions, followed by scale-up to meet target quantities and establishment of RP-HPLC purification methods.

The Results

Delivered the library on schedule, fully matching target purity and yield specifications. Provided a complete final report including full analytical datasets for all synthesized analogs.

Need expert peptide chemistry capabilities for your program?

From a single challenging sequence to a full SAR library or IND-enabling batch, tell us about your project and we'll come back to you within 48 hours.