Custom Synthesis & Route Scouting

Oxeltis delivers high-purity, scalable compounds through expert route scouting and precision synthesis, keeping your drug discovery program on time and on spec at every stage.

01 - SERVICE DESCRIPTION

The Oxeltis Advantage: Precision, Scalability, and Speed

Custom synthesis sits at the heart of every medicinal chemistry program — yet sourcing complex, high-purity compounds at the right scale and timeline remains one of the most persistent bottlenecks in drug discovery. Oxeltis combines scientific rigor with operational precision to deliver compounds that propel your programs forward, from early hit exploration to the multi-gram quantities required for ADME, toxicology, and IND-enabling studies.

before committing to synthesis, our PhD-level chemists identify the most efficient, cost-effective, and scalable synthetic pathways for your target molecule. This upfront investment in route design minimizes downstream risks, eliminates costly dead ends, and ensures that the chemistry supporting your program is built on solid, reproducible foundations from day one.

Purity and analytical rigor are non-negotiable. Our hybrid SFC purification and prep HPLC platform, combined with LC-MS, NMR, and HRMS analytics, ensures that every compound delivered meets the most stringent regulatory from trace impurity identification to full structural confirmation. Whether you require a single analog for a critical SAR experiment or a multi-gram batch for preclinical studies.

Key deliverables

Route scouting report

with recommended synthetic pathway, feasibility assessment, and risk analysis

Custom synthesis

of target compounds from mg to multi-gram scale

Full analytical package

LC-MS, NMR, HRMS, purity by HPLC

SFC purification

for chiral and achiral separations

Intermediates and building blocks

synthesis with documented synthetic route

Detailed project report

with experimental procedures, spectroscopic data, and CoA

Compound classes & therapeutic areas

Small molecules
Heterocycles
Nucleosides & nucleotides
Peptides
PROTACs
Molecular Glues
Oncology
Virology
Neurology
Rare diseases

02 — PROCESS / HOW IT WORKS

How our Custom Synthesis & Route Scouting service works

Project Scoping & Route Scouting

We assess your target structure, desired scale, and timeline. Our team identifies the optimal synthetic route — balancing efficiency, cost, and scalability before a single reaction is run.

Feasibility & Risk Assessment

A written feasibility report is delivered, detailing the proposed route, key synthetic challenges, alternative pathways, and a realistic timeline and cost estimate for your approval.

Synthesis & Purification

Our chemists execute the agreed route with rigorous quality controls at each step. SFC purification and real-time analytical monitoring ensure every intermediate and final compound meets specification.

Delivery & Full Documentation

Compounds are delivered with a complete analytical package (NMR, MS, HPLC purity), ready for downstream biological testing.

03 — USE CASES / APPLICATIONS

Where Custom Synthesis & Route Scouting makes the biggest difference

Hit & Lead Exploration

You have computationally or experimentally identified promising scaffolds and need focused analog libraries to establish SAR. We synthesize discrete compounds or small arrays with rapid turnaround, fueling your hit-to-lead decision making.

Outcome: mg-scale analogs delivered with full analytics, ready for immediate biological screening

Complex & Novel Target Molecules

Your target molecule presents significant synthetic challenges — strained rings, multiple stereocenters, sensitive functional groups, or poorly precedented chemistry. Our route scouting expertise identifies viable pathways where others have failed.

Outcome: successful synthesis of challenging structures with documented, reproducible routes

Scale-Up for Preclinical Studies

Your lead compound has been selected and you need multi-gram quantities for ADME, in vivo toxicology, or IND-enabling studies. We scale the chemistry seamlessly, maintaining purity and reproducibility at each step.

Outcome: Non-GMP gram to hundred-grams batches

Ready to turn your synthetic challenge into a delivered compound?

Share your target structure and project stage — we'll respond within 48 hours with a route scouting proposal and quote.

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